Plasma

Plasma-derived medicines are unique biologic medicines that treat people with plasma protein deficiencies and dysfunctions. The source material for manufacturing these medicines comes only from human donations. For most of the conditions that plasma-derived medicines treat, patients have no alternative treatment.

Without plasma donations, treatment would be unavailable, putting the lives of many patients at risk.

Alpha1 Proteinase inhibitor 3d shape in blue, customized according to PPTA's branding.Alpha1 Proteinase inhibitor 3d shape in blue, customized according to PPTA's branding.Alpha1 Proteinase inhibitor 3d shape in blue, customized according to PPTA's branding.

What is plasma?

Plasma is the single largest component of human blood and acts as a transporting medium for cells and a variety of substances vital to the human body. It contains water, salts, enzymes, antibodies, and other proteins. Plasma also carries out many critical functions, including fighting diseases, and is, therefore, essential for numerous therapies.

92%

Water

7%

Proteins

1%

Other
solutions
Other solutions/water or plasma 3d shape in blue, customized according to PPTA's branding.Protein 3d shape in blue, customized according to PPTA's branding.Other solutions/water or plasma 3d shape in blue, customized according to PPTA's branding.

Plasma: More Than Just Blood

Whole blood and blood component donations are mostly used in hospitals for transfusions required during surgery or other medical treatments. Source plasma donations are used to manufacture lifesaving plasma-derived medicinal products.

Source plasma

illustration of how the source plasma is is collected

Source plasma

Source plasma is collected through plasmapheresis, where plasma is separated from blood before the remaining components are returned to the donor’s body. It is used exclusively for manufacturing into final therapies.

illustration of how the source plasma is is collected

Source plasma

Source plasma is collected through plasmapheresis, where plasma is separated from blood before the remaining components are returned to the donor’s body. It is used exclusively for manufacturing into final therapies.

Plasma is essential

Plasma is not only essential for unique lifesaving therapies that treat rare and chronic diseases but also for everyday medicine, emergencies, surgical and preventive medicine. Find out more about what plasma in everyday medicine is used to treat.

Plasma protein
Used to treat
Outcomes
Immunoglobulins
  • Immunology-Immunodeficiencies
  • Neurology-Immune-mediated diseases
  • Hematology
  • Dermatology
  • Infection prevention
  • Regulation of overreacting immune system
  • Improved quality of life
  • Increased life expectancy
Clotting factors
  • Bleeding from trauma
  • Over dosage of anticoagulants
  • Liver disease
  • Bleeding Disorders
  • Other rare coagulation disorders
  • Improved quality of life
  • Increased life expectancy
C1 esterase inhibitor
  • Hereditary Angioedema
  • Improved quality of life
  • Increased life expectancy
Alpha-1 proteinase inhibitor
  • Alpha-1 Antitrypsin Deficiency
  • Improved quality of life
  • Halts disease progression
Hyperimmune Globulins
  • Prevention
  • Treatment
  • Protection of babies in utero
  • Rabies, tetanus and hepatitis
  • Rh negative pregnancy
  • Transplant therapy
Albumin
  • Cardiac surgery
  • Liver disease
  • Severe infections
  • Emergency and Surgical Medicine
  • Lifesaving in severe situations
  • Decreased morbidity and mortality
See full list

PLASMA PROTEIN

Immunoglobulins

USED TO TREAT
Immunology-Immunodeficiencies
Neurology-Immune-mediated diseases
Haematology
Dermatology
OUTCOMES
Infection prevention
Regulation of overreacting immune system
Improved quality of life
Increased life expectancy

PLASMA PROTEIN

Clotting factors

USED TO TREAT
Immunology-Immunodeficiencies
Neurology-Immune-mediated diseases
Haematology
Dermatology
OUTCOMES
Infection prevention
Regulation of overreacting immune system
Improved quality of life
Increased life expectancy

PLASMA PROTEIN

C1 esterase inhibitor

USED TO TREAT
Hereditary Angioedema
OUTCOMES
Improved quality of life
Increased life expectancy

PLASMA PROTEIN

Alpha-1 proteinase inhibitor

USED TO TREAT
Alpha-1 Antitrypsin Deficiency
OUTCOMES
Improved quality of life
Halts disease progression
See full therapies list
See less
3d shape in blue, customized according to PPTA's branding3d shape in blue, customized according to PPTA's branding

Plasma for your everyday medicines

Plasma is not only essential for treating rare and chronic diseases — find out more about how plasma is used for everyday medicine, emergencies, and surgical preventive medicine.

image of woman with glasses smiling for the camera
A young woman during the plasma donation process.
A lady and a women are hugging each other.
A young woman during the plasma donation process.

THE Value of plasma To SOCIETY

Plasma-derived medicines are high-impact pharmaceuticals that provide lifelong benefits to patients. Over the years, these medicines have delivered significant value to society through increased life expectancy, improved quality of life, and reduced life-threatening complications for individuals with plasma protein deficiencies.

As policies to slow health spending are debated, it is critical to maintain access to lifesaving treatments for rare disease patients.

10-YEAR SURVIVAL RATE OF PATIENTS WITH COMMON VARIABLE IMMUNE DEFICIENCY, BY YEAR
Source: Chapel H, Lucas M, Lee M, et al. Common variable immunodeficiency disorders: Division into distinct clinical phenotypes. Blood. 2008; 112(2):277–286.
LIFE EXPECTANCY OF A PATIENT BORN WITH HEMOPHILIA,
BY YEAR
Source: Aledort, L. The evolution of comprehensive haemophilia care in the United States: Perspectives from the frontline. Haemophilia. 2016; 22(2):676-683.

THE Value of plasma to patients

Medicines made with plasma are often the only and most effective therapies for many rare and chronic diseases. Each therapy is unique due to the pharmacologic and manufacturing differences that exist across different brands and patients’ unique response to the treatments. Plasma-derived medicines are non-interchangeable, sole-source biologics, therefore it is essential that patients have access to their medically justifiable therapy.

Donate now
Donate now

Find a donation cenTRE

Locate your nearest plasma centre by entering a city or a postal code of your area in the search bar below:

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Support the need to increase plasma donations in Europe

By signing, you will show your support for increasing plasma collection in Europe, which is essential to treat patients who rely on plasma-derived medicines.

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two children smiling next to each other, holding up signs that say worth a cure
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